Lung cancer is the leading cause of cancer death, accounting for 18.4% of the total cancer deaths worldwide. Despite major advances in cancer care, lung cancer is associated with a high mortality rate, in part because of late-stage diagnosis, for which the 5-year survival rate is approximately 4%.

A proteogenomic study revealed sex- and smoking-related differences, proteomic subtypes that may be associated with clinical outcomes, and potential biomarkers for therapeutic intervention.

Emerging biomarkers hold promise for better selecting patients with non–small cell lung cancer (NSCLC) who are good candidates for immune checkpoint inhibitors, according to a review published in the journal Cancer.

A diagnosis of small-cell lung cancer (SCLC) carries with it a grim prognosis. Standard therapy for extensive-stage disease, which consists of combination chemotherapy and radiation, is associated with 5-year overall survival rates of just 5%-10%.

BY CHRISTINE KILGORE MDedge News SAN FRANCISCO – For patients with non–small cell lung cancer, the ratio of neutrophils to lymphocytes appears to be predictive of response to immune checkpoint inhibitors, a finding that could aid in treatment planning, investigators...

BY CHRISTINE KILGORE MDedge News For patients with non–small cell lung cancer (NSCLC), a blood test of tumor mutational burden (TMB) could predict clinical responses to checkpoint inhibitors, according to investigators. The blood panel, which included 150 genes,...

BY CHRISTINE KILGORE MDedge News FROM THE JOURNAL FOR IMMUNOTHERAPY OF CANCER About two out of three patients with small cell lung cancer (SCLC) express B7-H3, a B7 family ligand that may one day serve as a therapeutic target, according to investigators....